A recent study of breast cancer patients may help doctors reduce the common side effects of treatment options. A study conducted by Dr. Eva Sevick, director of the Center for Molecular Imaging at the University of Texas Medical School (UTHSC) in Houston, and Dr. Caraline Eife, director of the UHTSC Herman Honors Trauma Care Center, can alleviate suffering for millions of patients. Their paper was published in the inaugural issue of Biomedical Optics Letters, an online, open journal published by the American Optical Society (OSA). The articles published in the magazine will focus on the combination of theoretical models and simulations, technology development, biomedical research and clinical applications. It is understood that a considerable number of breast cancer patients have complications of lymphedema after surgery. Due to lymphedema, fluid accumulates in the upper limbs, which is very likely to cause deformation of the limbs or edema of the prisoner's limbs, which greatly affects the quality of life of patients. Although the treatment methods for this phenomenon vary, in general, they include the use of manual and pneumatic therapy to "push" or stimulate the body to expel excess fluid to reduce tissue edema. It usually takes several months to test whether a treatment is effective. The reason for this phenomenon is mainly because the existing method of evaluating the efficacy of the limbs by measuring the circumference or volume of the limb to determine the degree of change in edema-and this change is large enough to measure often takes a considerable amount of time. During this time, the situation may improve-or it may deteriorate further. The UTHSC research team has developed a promising method for more sensitive and faster efficacy testing. They used the latest near-infrared fluorescence imaging technology to monitor the origin of lymphedema: due to blockage or damage to the lymphatic system, the lymph fluid cannot circulate through the body normally and accumulate in the limbs. "The lymphatic system is like a drain in your body," Sevick said. "If they are all blocked, sooner or later they will explode." Nine female subjects, including 6 patients with lymphedema and 3 controls, received an injection of near-infrared fluorescent imaging dye, which has been used safely at higher doses for 50 years. This dye is taken up by the lymphatic system. When the surface of the tissue is exposed to a weak, near-infrared laser that is almost harmless to the human body, the fluorescent dye will show its movement in the lymphatic system without reservation. "This is the only method that can directly determine whether the lymphatic system function has improved before and after treatment," Sevick said. Clinicians usually have several treatments to control lymphedema. They may use compression bandages or massage the limbs to artificially promote the discharge of fluids from the limbs. Inflation and squeezing through an inflatable compression device or sleeves made from multiple compartments may provide similar treatment at home. But they are not all included in the category of medical insurance because of the lack of relevant clinical evidence. "The biggest problem is that there has never been a good way to evaluate the effect of treatment," Sevick said, "but the good news is that we can use near infrared fluorescence imaging technology to improve the lymphatic system function brought about by these treatments. show out." After treatment with an inflatable compression device, a statistically significant improvement in the lymphatic system has been immediately detected by near infrared fluorescence technology. However, Sevick said that a larger follow-up study is still needed to confirm the results of this prospective trial.
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